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GSK submits first regulatory application for daprodustat in Japan for patients with renal anaemia due to chronic kidney disease

Issued: London, UK GlaxoSmithKline plc (LSE/NYSE: GSK) today announced the submission of a Japanese New Drug Application (JNDA) to the Ministry of Health, Labour and Welfare seeking marketing approval for daprodustat, an oral hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI), for the treatment of patients with renal anaemia due to chronic kidney disease (CKD). Dr Hal Barron, Chief Scientific Officer and...

The Nobel Prize in Physiology or Medicine 2019

English English (pdf) Swedish Swedish (pdf)[1][2][3] 2019-10-07 The Nobel Assembly at Karolinska Institutet[4] has today decided to award the 2019 Nobel Prize in Physiology or Medicine jointly to William G. Kaelin Jr., Sir Peter J. Ratcliffe and Gregg L. Semenza for their discoveries of how cells sense and adapt to oxygen availability SUMMARY Animals need oxygen for the conversion of...

Oxygen delivery and haemoglobin

Abstract Oxygen must be transported effectively from the atmosphere to the tissues in order to sustain normal metabolism. An understanding of oxygen delivery is therefore central to the management of patients during anaesthesia, resuscitation and during critical illness. This review deals specifically with the transport of oxygen from the lungs to non-pulmonary tissues. Key points Oxygen is carried in arterial...